The radical possibilities of man-made DNA | Floyd E. Romesberg

Every cell that’s ever lived has been the result of the four-letter genetic alphabet: A, T, C and G — the basic units of DNA. But now that’s changed. In a visionary talk, synthetic biologist Floyd E. Romesberg introduces us to the first living organisms created with six-letter DNA — the four natural letters plus two new man-made ones, X and Y — and explores how this breakthrough could challenge our basic understanding of nature’s design.

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Your fingerprints reveal more than you think | Simona Francese

Our fingerprints are what make us unique — but they’re also home to a world of information hidden in molecules that reveal our actions, lifestyles and routines. In this riveting talk, chemist Simona Francese shows how she studies these microscopic traces using mass spectrometry, a technology that analyzes fingerprints in previously impossible detail, and demonstrates how this cutting-edge forensic science can help police catch criminals.

Check out more TED Talks: http://www.ted.com

The TED Talks channel features the best talks and performances from the TED Conference, where the world’s leading thinkers and doers give the talk of their lives in 18 minutes (or less). Look for talks on Technology, Entertainment and Design — plus science, business, global issues, the arts and more.

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How data is helping us unravel the mysteries of the brain | Steve McCarroll

Geneticist Steve McCarroll wants to make an atlas of all the cells in the human body so that we can understand in precise detail how specific genes work, especially in the brain. In this fascinating talk, he shares his team’s progress — including their invention of “Drop-seq,” a technology that allows scientists to analyze individual cells at a scale that was never before possible — and describes how this research could lead to new ways of treating mental illnesses like schizophrenia.

Check out more TED Talks: http://www.ted.com

The TED Talks channel features the best talks and performances from the TED Conference, where the world’s leading thinkers and doers give the talk of their lives in 18 minutes (or less). Look for talks on Technology, Entertainment and Design — plus science, business, global issues, the arts and more.

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Nanobot (Havana Parody) | A Capella Science ft. Dorothy Andrusiak

A sensuous song of molecular machines.
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MP3: https://timblais.bandcamp.com/track/nanobot
—————-
A CAPELLA SCIENCE STUFF:
Patreon: http://patreon.com/acapellascience
Facebook: http://facebook.com/acapellascience
Twitter: http://twitter.com/acapellascience
Instagram: http://instagram.com/acapellascience
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Follow me @acapellascience on Twitter, Instagram, Snapchat!
—————-
DOROTHY ANDRUSIAK STUFF:
Facebook: http://facebook.com/dorothyandrusiak
Instagram: https://instagram.com/andrusiak.1/
—————-
EPRSC LINKS:
EPSRC Molecular Robotics program: http://gow.epsrc.ac.uk/NGBOViewGrant.aspx?GrantRef=EP/P027067/1
Prof Dave Leigh group webpage: http://www.catenane.net
—————-
REFERENCES:
[1] http://www.catenane.net/pdfs/articles/2010walker_naturechem.pdf
[2] https://pubs.acs.org/doi/pdf/10.1021/ja058303m
[3] https://www.nature.com/articles/nature05452
[4] https://pubs.acs.org/doi/pdf/10.1021/ja904104c
[5] https://pubs.acs.org/doi/pdf/10.1021/ol102422h
[6] http://pubs.rsc.org/en/content/articlehtml/2016/cc/c6cc08586e
[7] https://www.nature.com/articles/nature23677
[8] http://pubs.rsc.org/en/Content/ArticleLanding/1994/C3/C39940001213#!divAbstract
[9] https://pubs.acs.org/doi/pdf/10.1021/ol0487985
[10] https://pubs.acs.org/doi/pdf/10.1021/ja9712229
[11] http://rotaxane.net/pdfs/articles/Leigh%20Sequential%20Peptide%20Synthesis%20Science%202013.pdf
[12] https://pubs.acs.org/doi/pdf/10.1021/ja908524x
[13] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504628/
[14] https://www.youtube.com/watch?v=b_cp8MsnZFA
[15] https://www.wehi.edu.au/wehi-tv/chromosome-and-kinetochore
[16] https://www.wehi.edu.au/wehi-tv/x-inactivation-and-epigenetics
[17] https://www.wehi.edu.au/wehi-tv/molecular-visualisations-dna
[18] ‘Inner Life of the Cell,’ © 2006 President and Fellows of Harvard College. Created by Alain
Viel, PhD and Robert Lue, PhD in collaboration with XVIVO, LLC and John Liebler, Lead
Animator. Made possible through the generous support of the Howard Hughes Medical
Institution’s Undergraduate Science Education Program.
—————-
NANOBOT
(Music: ‘Havana’ by Camila Cabello)

To plan a nanobot
Map out the molecules to span the nanobot
Add on the motors used to man the nanobot
Signals to talk with a commander
Software and logic’s grammar
Programmed in nanobot

Beginning you better control the movement
(The thermal storm abrew)
Room temperature systems are always moving
(Your system’s moving too)
The pieces and links you pick will
limit
(The states it can assume)
As is it’ll randomly shuffle through them

Now force it with the right
Fuel
Ordered and energetic
A bias in the setup
Adding entropy through
A cycle that’ll let it
Put work to load
Oh na na nanobot

So plan your nanobot
With steps whose opposite’ll jam the nanobot
Barriers free energy expenditure will drop
To let it pass and then to catch it
Go through the door and latch it
A ratchet nanobot

Let’s see
You’ve animated these lil’ gadgets? Damn!
Next let’s see you handle informatics fam
(Nano-informatics)
1-0 the structure of a cache or RAM
Switches are the way to data save and plan (flip it on)
Flip it chemically
Photochemically
Or electrically
Add a flippable knee (then what?)
Make a little more deep
The decisional tree (data)
If you need a calculator how be
Logic gates, like “a, not b”
Input’s a cation, as key (that’s key)
And you get a photon as a reading

So plan your nanobot
To be in part an info scanner nanobot
Reading and writing coded data that allot
Freedom to do as you program it
A Turing automatic
Full gamut nanobot

Doesn’t that look life-like? (x3)

(Break me down I am)

A metananobot
The muse and model of synthetic nanobots
Working in concert as a replicable lot
For all I try to be more than it
Though sentient and organic
I am a nanobot

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